Testosterone Doesn’t Increase Risk of Heart Attack or Stroke

New Study—Testosterone Does Not Increase Heart Attack or Stroke Risk

Two recent studies, both with significant flaws, have garnered a great deal of attention from the media as well as opportunistic lawyers by questioning the safety of testosterone therapy. The Veteran’s Administration study, published in the November issue of JAMA (the Journal of the American Medical Association), is the most controversial, with experts from all over the world calling for JAMA to retract the study.

In contrast to these negative studies, a new retrospective study presented at the American Association of Clinical Endocrinologists (AACE) 23rd Annual Scientific and Clinical Congress has found that testosterone therapy in men was not associated with an increased risk for heart attack or stroke, and may even be protective.

In the latest study, nearly 20,000 men with low testosterone received testosterone therapy over a 5-year period (2009–2014) at hormone clinics across the US. The researchers found that the risk for heart attack was 7-fold lower, and the risk for stroke was 9 times lower in patients treated with testosterone compared with samples from the general population. Furthermore, there was no evidence of a worse outcome in treated patients with known heart disease.

Key differences in the new study compared to the 2 recent negative studies include:

  • Testosterone levels and hemoglobin were routinely monitored. Injectable testosterone was used as opposed to topical forms (patches and gels).
  • There were markedly fewer heart attacks and strokes, not more.
  • Patients with a history of heart disease did not have worse outcomes.

Testosterone replacement therapy should only be done after a thorough evaluation and be prescribed by those experienced with its use and the nuances of treatment. At Cenegenics, we have treated over 35,000 patients with hormone therapy. We monitor our patients closely, and always, after an extensive evaluation, use the testosterone preparation that would work the best for you. Our patients have experienced extraordinarily low rates not only of heart attack and stroke, but also cancer, diabetes and osteoporosis among others.

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